请仔细阅说明书并按照说明使用或在医生与药师指导下购买和使用。
Please read the instructions carefully and use according to the instructions or purchase and use under the guidance of a doctor or pharmacist.
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1. 自己HIV为阴性，且检测结果一月内无高危性行为； 2. 肝肾功能处于正常状态。 服用前请至医院筛检以下项目：
1. You ARE HIV-Negative, and no high-risk sexual behavior within one month of the test result;
2. Liver and kidney function are in normal state.
Please go to the hospital to screen the following items before taking:
· Confirm HIV-negative
· Confirm kidney function Creatinine Clearance (CrCl) creatinine clearance>=60ml/min
· Test B and C hepatitis status: If you are infected with chronic hepatitis, further liver function test is required
· STD tests: such as syphilis, gonorrhea, chlamydia infection, etc. If you have STD, you will need to treat it first before taking PrEP.
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注意事项 | Precautions |
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1. PrEP作为预防药物，并不能完全保护您不受感染，每日定时服药，让药物浓度保持在一定水平能让您降低感染几率。 2. 随意断药、漏服都会导致药物浓度降低并增大感染几率（断药、漏服期间产生高危行为的，不仅有感染风险，还会带来耐药风险，让此后的治疗更为复杂）。 3. 男男性交受入方，服药7天后直肠药物浓度方能达到稳定值，女性服药21天后，阴道药物方能达到稳定值。 4. 不建议在服用期间尝试任何无保护行为，服用期间必须正确使用安全套，PrEP不能保护您不受其他性病感染，如梅毒、HPV等，也不能预防怀孕。 5. 有严重肝肾功能障碍人士，如正在感染乙肝的人士，请在服用前咨询专科医生。 6. 服用首月后及服用3个月后定期检查HIV及肝肾功能。 7. 如你需要在服用PrEP期间使用其他药物，请提前进行药物相互作用查询，在确保无相互作用的情况下合理使用。 1. PrEP is a preventive drug, which cannot completely protect you from infection. Taking the drug regularly every day and keeping the drug concentration at a certain level can reduce your chance of infection. 2. Randomly stopping the drug or missing a dose will lead to a decrease in drug concentration and increase the chance of infection (high-risk behaviors during the period of stopping the drug or missing a dose will not only increase the risk of infection, but also bring the risk of drug resistance, making subsequent treatment more complicated). 3. For MSM intercourse, the blood concentration can reach a stable value after 7 days of taking the drug, and the for women, may need to take the drug for 21 days for reach Stable blood concentration. 4. It is not recommended to practice any unprotected sex during the period of taking the drug. Condoms must be used correctly during the period of taking PrEP. PrEP cannot protect you from other sexually transmitted diseases, such as syphilis, HPV, etc., nor can it prevent pregnancy. 5. People with severe liver and kidney dysfunction, such as those who are currently infected with hepatitis B, please consult a specialist before taking the drug. 6. Regularly check HIV and liver and kidney function after the first month of taking the drug and after 3 months of taking PrEP. 7. If you need to use other drugs while taking PrEP, please check drug interactions in advance and use them reasonably after ensuring that there are no interactions.
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副作用 Side Effects |
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PrEP的副作用因人而异，目前为止该药物还未出现过严重副作用的案例。短期副作用包括头痛、肠胃不适与食欲不振、疲倦及体重减轻。在一些研究中，有2%服用PrEP的人士有肌酐清除率和肾小球滤过率轻微减少，以及骨质密度轻微流失的情况。但一般人士在停止服用PrEP后，副作用都会消失。
The side effects of PrEP vary from person to person, and so far there have been no cases of serious side effects of the drug. Short-term side effects include headaches, gastrointestinal discomfort and loss of appetite, fatigue, and weight loss. In some studies, 2% of people taking PrEP had a slight decrease in creatinine clearance and glomerular filtration rate, as well as a slight loss of bone density. However, the side effects generally disappear after people stop taking PrEP.
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如何使用 Direction for Use |
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按日服用 / Taking daily 服用方法：每日1片 需要每天在同一时间服用PrEP，让它成为您日常工作的一部分，可将PrEP放在牙刷旁边或床头，并每天起床或睡前后服用PrEP。这有益于让你养成使用PrEP的习惯。 每日PrEP的优势：按日服用PrEP能给你带来更高的保护效率。即使某天突然忘记服用，体内PrEP的药物浓度依然可以对您进行保护！ 适用人群：适用于所有人，特别是性爱频繁且有漏服经历的使用者。 *达可辉优先按照此方案使用。（按需使用达可辉有效率数据有待更新，在专业机构评估数据更新前，强烈建议您优先遵照按日服用方案进行使用） Dosage: 1 tablet per day PrEP needs to be taken at the same time every day, making it part of your daily routine. You can put PrEP next to your toothbrush or bedside, and take PrEP every day before and after getting up or going to bed. This helps you develop a habit of using PrEP. Advantages of daily PrEP: Taking PrEP daily can give you higher protection efficiency. Even if you suddenly forget to take it one day, the drug concentration of PrEP in your body can still protect you! Applicable people: Suitable for everyone, especially users who have frequent sex and have missed doses. *Descovy and realted generic Drugs should be used according to this plan first. (The data on the effectiveness of using Descovy by on-demand is insufficient. Before CDC update other directions, it is strongly recommended that you follow the daily dosing plan first) 按需服用 \ On-Demand 该服用方式不适用于女性（生理女性）/及乙肝患者 服用方法：发生性行为前2-24小时内服用2粒，距离首次服用后24小时后再服用1粒，距离首次服用后48小时后再服用1粒，共4粒。 适用人群：生理男性，且性生活不频繁。 This method of taking is not suitable for women (physiological women)/and hepatitis B patients How to take: Take 2 capsules within 2-24 hours before sexual intercourse, take another capsule 24 hours after the first dose, and take another capsule 48 hours after the first dose, a total of 4 capsules. Applicable people: Physiological men, and people have less sexual activity. |
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如果在按需服用期间有连续性行为，可在最后一次性行为发生后再连续服用2日即可。If you have continuous sexual intercourse during the on-demand medication period, you can continue taking the medicine for 2 consecutive days after the last sexual intercourse.
无论你采用何种服用方案，都需要按时服用，使用手机给自己设置定时提醒，或购买7日装小药盒。如有发现漏服应该及时补服，不稳定的药物浓度会带来潜在的耐药风险。 服用前与你的专科医生讨论自己适合何种服用方案，如果在服用过程中，你有发现你会存在经常漏服的情况，那么其实按日服用会更适合你。 No matter what plan you adopt, remember to take it on time, use your mobile phone to set a reminder, or buy a 7-day medicine box. If you find that you miss a dose, you should take it ASAP. Unstable blood concentration will bring potential drug resistance. Discuss with your doctor before taking, get to know which plan is suitable for you. If you find that you often miss doses , then taking it daily will be more suitable for you.
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停用与再次使用 ｜Re-administration |
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根据现有的不同PrEP指导方针，大多数方案都同意的一点是：对于正在使用PrEP的人，如男男性交，他们采用事件驱动服用PrEP策略，使用者应在最后一次暴露后继续服用PrEP 2天。但如果是通过阴道开展的性行为，则推荐女性在最后一次潜在的HIV暴露后7天到28天持续服用（各指导版本会有不同）。因此我们会看出，对于性别上的PrEP停用，会产生不同。且基于最后一次暴露的风险等级，建议的持续时间也会不同。 EnvoyMeds建议，基于你的暴露情况，安全停用： 有暴露风险的男性，暴露后持续服用10天后停用；有暴露风险的女性，暴露后持续服用28天。无暴露风险的男性，性行为后持续使用2天；无暴露风险的女性，性行为后持续服用10天。 再次使用前：检测HIV及检测肝肾状况，评估潜在风险后再次启用。 According to the different existing PrEP guidelines, most programs agree that for people who are using PrEP, such as men who have sex with men, and taking PrEP on-demand, should continue to take PrEP for 2 days after the last exposure. However, if it is vaginal sex, it is recommended that women continue to take it for 7 to 28 days after the last potential HIV exposure (various versions of the guidelines suggest vary). Therefore, we can see that there will be differences in PrEP discontinuation for gender. And based on the risk level of the last exposure, the recommended duration will also be different. EnvoyMeds recommends that you stop using PrEP based on your last potential HIV exposure: For men at risk of exposure, continue to take it for 10 days after last exposure and then stop; for women at risk of exposure, continue to take it for 28 days after exposure. For men without risk of exposure, continue to use it for 2 days after sexual intercourse; for women without risk of exposure, continue to take it for 10 days after sexual intercourse. Before re-administration: Test HIV and liver and kidney status, and start taking after evaluating potential risks.
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产品储藏 | Storage |
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开启后请原瓶储存，保存在30摄氏度以下无阳光直射，不需要放冰箱；如需额外分装至小药盒也应尽快使用。药瓶开启后应尽量在3月内使用完毕以保证药效稳定。 After opening, please store the original bottle at a temperature below 30 degrees Celsius and away from direct sunlight. No need to put into a refrigerate. If you need to divide the bottle into small medicine boxes, use them as soon as possible. After opening the bottle, try to use it within 3 months to ensure the stability of the efficacy. |
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如您还有更多关于PrEP使用的疑问并希望了解更多，可登陆EnvoyMeds官网，或与我们的人工客服取得联系。 感谢您对防艾工作所做出的贡献，让我们一起携手迈向世卫2030“0艾滋”目标。 If you have more questions about the use of PrEP and want to learn more, you can visit EnvoyMeds official website or contact our customer service. Thank you for your contribution to AIDS prevention. Let us work together to move towards the WHO’s 2030 “0 AIDS” goal. |
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